Core Leads: Dr. Megan Levings (BCCHR, UBC Professor), Dr. Francis Lynn (BCCHR, UBC Professor) & Dr. Marc Horwitz (UBC Professor).
Core Objective: To support the need of investigators within the Breakthrough T1D Centre of Excellence at UBC to test the in vivo function of engineered immune cells and model immune-islet cell interactions using humanized mice. Support will be provided for three different models.
Images of a non-rejected human islet retrieved from an islet transplant in the anterior chamber of the eye. Left image shows a classical histology image. The right image shows the same human islet now fluorescently labelled for insulin (green) and an immune cell marker (red). Notice the difference between this non-rejected islet and the rejected islet below. Images of a rejected human islet retrieved from an islet transplant in the anterior chamber of the eye. Left image shows a classical histology image. The right image shows the same human islet now fluorescently labelled for insulin (green) and an immune cell marker (red). These images are kindly provided by Dr Majid Mojibian from the Levings lab.
